My Album of The Month (June 2011)

If you'd asked , i'd definitely say it was Gavin Hayes' voice , lurking in my ears all these long days.
Two thumbs up Dredg , Two Thumbs up "The Pariah, the Parrot, the Delusion".Their fantastic concept album is a fair mix of Progressive Rock and experimental music .Gavin Hayes' vocal's adorable.

ADT for Prostate Cancer

In the 1990s, reversible androgen suppression with the use of luteinizing hormone–releasing hormone analogues and oral antiandrogen agents was shown to induce apoptotic regression in androgen-responsive cancers, potentially improving the prospects of local control and the duration of survival free of metastatic disease.
Clinical Pearls

How can short-term androgen deprivation be achieved?
In this study, patients assigned to short-term androgen-deprivation therapy (ADT) received flutamide at a dose of 250 mg orally three times a day and either monthly subcutaneous goserelin at a dose of 3.6 mg or intramuscular leuprolide at a dose of 7.5 mg for 4 months.
How more effective was ADT with radiotherapy as compared to radiotherapy alone for patients with localized prostate cancer in this study?
According to the results of this study, the 10-year rate of overall survival was 62% among patients receiving radiotherapy plus short-term ADT (the combined-therapy group) versus 57% among patients receiving radiotherapy alone (hazard ratio for death with radiotherapy alone, 1.17; P=0.03). The addition of short-term ADT was associated with a decrease in the 10-year disease-specific mortality from 8% to 4% (hazard ratio for radiotherapy alone, 1.87; P=0.001).
Morning Report Questions
Q. Which group of patients benefited the most from ADT in this study?
A. The addition of short-term ADT to radiotherapy conferred the greatest clinical benefit in the intermediate-risk subgroup, with an increase in the 10-year rate of overall survival from 54 to 61% and a reduction in the 10-year disease-specific mortality from 10 to 3%.
Q. What are adverse effects of ADT?
A. In prospective studies, short-term ADT caused measurable muscle loss, fat accumulation, decreased insulin sensitivity, and increased cholesterol and triglyceride levels.
@NEJM

This Crazy Summer

Is he coming?

Business and Healthcare;Entrepreneurship Joints?

Part-maverick, part-unconventional, part-smart business owner Sir Richard Branson has business lessons to share in spades. Since I recently read his third autobiographical book Business Stripped Bare: Adventures of a Global Entrepreneur, I wanted to pass on some of what I learned from the book.

Without knowing exactly why, I have long admired his acumen and chutzpah. His story has provided me insights into why I’ve been so drawn to his adventures in business and his larger-than-life personality.
For those of you who don’t know much about him, Branson is the product of a somewhat privileged middle-class upbringing (he descends from a line of barristers and judges) and an English public school (what we in the US call a private school). A self-proclaimed poor student with dyslexia, he failed to complete any college degree, but opted instead to start a business, first as a magazine publisher and then as a mail-order record company owner. He went on to found Virgin Records, and this single venture expanded over the decades to become the Virgin Group, a conglomerate of businesses focused on travel (planes, trains, space travel), entertainment and lifestyle (including humanitarian ventures like fighting HIV, AIDS and climate change).
I came away with many business lessons. Here are a few.
Branson’s business philosophy is crystallized in these words, when asked why he went into business:
I’ve never been interested in being ‘in business’. I’ve been interested in creating things … Business is creative. It’s like painting. You start with a blank canvas. You can paint anything – anything – right there, is your first problem. For every good painting you might turn out, there are a zillion bad paintings just aching to drip off your brush. Scared? You should be. You start. You pick a color. The next color you pick has to work with the first color … People who succeed in business have swallowed their fear and have set out to create something special, something to make a difference to people’s lives …
Lesson: To thrive in business, it really helps to be passionate about creating something worthwhile. As a relative newcomer to entrepreneurship, I have maintained for years now that being an entrepreneur is a radical act of creativity, and it makes an every day “practice” so much more fun once you think of it as an entrepreneurial venture.
His fiercely independent path to success, in the face of rampant naysayers and critics, is both inspirational and hard to imagine duplicating. His gut instincts have won out many times over the analytics and pompous prognostications of others. He’s a master as staying on course with his vision and sense of purpose and ignoring the conventional wisdom.
I’m not good at theory. Almost everything I’ve learned, I’ve learned by doing.
Lesson: While you may draw insight and inspiration from someone else’s success story, you must rely on knowledge about your own marketplace, along with your inner talents and skills, to forge your own path.
Branson has been driven by the desire to innovate, partly I suspect because it’s in his genetic make-up and partly because he has been an astute observer of his own ecosystem’s evolution.
The best, most solid way out of a crisis in a changing market is through experimentation and adaptation.
Lesson: Healthcare is in crisis and the market is changing. It’s vital that we, as providers in an unstable setting, experiment and adapt. New business models? New levels of customer service? New joint ventures, relationships, partnerships?
His two greatest secrets of business success, in my opinion?
1. His relentless focus on the Virgin brand, along with his absolute clarity about what the brand stands for.
2. His dogged insistence on placing the people who work for him first. Wouldn’t that be nice, in healthcare?
by Philippa Kennealy, MD, MPH

Listening To Lovers In Japan !

Lovers, keep on the road your on

Runners, until the race is run

Soldiers, you've got to soldier on

Sometimes even right is wrong

They are turning my head out

To see what I'm all about

Keeping my head down

To see what it feels like now

But I have no doubt

One day, were gonna get out

Tonight, maybe we're gonna run

Dreaming of the Osaka sun

Ohh, ohh, ohhh

Dreaming of when the morning comes

They are turning my head out

To see what I'm all about

Keeping my head down

To see what it feels like now

But I have no doubt

One day, the sun will come out

Truly amazing song ;p.

Pic : Martin Buzora

It's The Month of July

Today was the day of a fierce tete-a-tete.I'm gonna fight till the very end.Pedram,July 11 2011

Off To US

My Author of The Month (June 2011)

How i feel his vigorous presence in my life