From Greek origin meaning "without knowledge of the disease." You may also hear it called "lack of insight." What it boils down to is that the person is unaware of their condition and unable to accept it.
This is not a stubborn attitude or driven from denial. It is the brain being incapable of processing the fact that their thoughts and moods don’t reflect reality. Accompanied with confabulation (generation of fabricated stories that the patient believes to be true), and blindness are suggestive of damage to occipital lobes of the brain.
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